If you tell the AFC to add 15% fuel, it will do. If you tell it to remove 15% fuel, it will do that too. Injector control isn't the problem here, the problem is what happens to the spark advance.
Remember that the S-AFC alters the signal sent from the airflow meter to the ECU. The ECU has a preprogrammed map for both spark advance and injector opening times. It uses the reading from the air flow meter to calculate load, and the engine RPM, then looks up the correct fuel and advance settings from the preprogrammed maps. If you alter the air flow signal to make the ECU read a lower load cell in the fuel map, at the exact same time you make the ECU read a lower load cell in the spark advance map.
If you pull 20% fuel using an AFC by fooling the ECU in to thinking 20% less load is on the engine, depending on load you could add 10 degrees spark advance. Off boost you can run as much advance as you like without ever running in to a problem with detonation, however on boost the total advance is always knock limited. A good example of this would be,
No AFC, 440cc injectors, 15psi boost, 6500rpm = Injector time 14.6ms / Spark advance 22 degrees (total advance) AFR= 11.8:1
S-AFC pulling 40% fuel 700cc injectors, 15psi boost, 6500rpm = Injector time 8.76ms Spark advance 32 (total) AFR=11.8:1
That extra 10 degrees advance will cause the engine to detonate, and no, water injection isn't enough to prevent it.
You CAN NOT safely run 700cc injectors with just an S-AFC, you will need something to also control the timing too. By the time you've forked out for an AFC and ITC (timing controller) you could have already bought a standalone ECU like the SDR.
Don't try to save money on engine tuning because it always works out more expensive in the long run. If you are at the point where you need bigger injectors, you are also at the point where to make the most of your engine safely you need a stand alone ECU.
700cc injectors have enough fuel to make nearly 480 wheel horse power, so say if you run them safely at 85% duty that's still nearly 400hp at the wheels. To run that power you will have to run upwards of 26psi boost on at least a 50 trim T3/T4 (or GT30 for example). Our standard ECU only has timing maps up to around 13psi boost, after that point injector duty is maxed out and the spark advance holds it's total advance. To stop detonation you will have to pull timing from the top of the map anyway at that boost level, so making matters worse by having an AFC adding more advance will destroy your engine in no time.
An Apexi S-AFC is not a proper tuning tool, it's only good for making small adjustments to standard injectors. The second you start to pull more than 15% fuel, you will start to have problems with excessive advance. If you need further proof I suppose I could post up some maps from other cars I have tuned.